IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0165725.html
   My bibliography  Save this article

Prognostic Significance of High VEGF-C Expression for Patients with Breast Cancer: An Update Meta Analysis

Author

Listed:
  • Zhiqiao Zhang
  • Guanying Luo
  • Hongfeng Tang
  • Canchang Cheng
  • Peng Wang

Abstract

Background: The prognostic significance of vascular endothelial growth factor C (VEGF-C) expression in breast cancer (BC) patients remains controversial. Therefore, this meta-analysis was performed to determine the prognostic significance of VEGF-C expression in BC patients. Materials and Methods: Several electronic databases were searched from January 1991 to August 2016. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate the prognostic significance of VEGF-C expression for disease free survival (DFS) and overall survival (OS). Results: The present meta analysis totally included 21 eligible studies and 2828 patients with BC. The combined HRs were 1.87(95% CI 1.25–2.79, P = 0.001) for DFS and 1.96(95% CI 1.15–3.31, P = 0.001) for OS. The pooled HRs of non-Asian subgroup were 2.04(95%CI 1.36–3.05, P = 0.001) for DFS and 2.61(95%CI 1.51–4.52, P = 0.001) for OS, which were significantly higher than that of Asian subgroup. The funnel plot for publication bias was symmetrical. The further Egger's test and Begg's test did not detect significant publication bias (all P>0.05). Conclusions: The present meta analysis strongly supported the prognostic role of VEGF-C expression for DFS and OS in BC patients, especially for patients in non-Asian countries. Furthermore, stratification by VEGF-C expression may help to optimize the treatments and the integrated managements for BC patients.

Suggested Citation

  • Zhiqiao Zhang & Guanying Luo & Hongfeng Tang & Canchang Cheng & Peng Wang, 2016. "Prognostic Significance of High VEGF-C Expression for Patients with Breast Cancer: An Update Meta Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.
    • Handle: RePEc:plo:pone00:0165725
    DOI: 10.1371/journal.pone.0165725
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165725
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165725&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0165725?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Anna Goussia & Nafsika Simou & Flora Zagouri & Kyriaki Manousou & Georgios Lazaridis & Helen Gogas & Angelos Koutras & Maria Sotiropoulou & George Pentheroudakis & Dimitrios Bafaloukos & Christos Mark, 2018. "Associations of angiogenesis-related proteins with specific prognostic factors, breast cancer subtypes and survival outcome in early-stage breast cancer patients. A Hellenic Cooperative Oncology Group," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-19, July.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0165725. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.