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Switch to Ritonavir-Boosted versus Unboosted Atazanavir plus Raltegravir Dual-Drug Therapy Leads to Similar Efficacy and Safety Outcomes in Clinical Practice

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  • Pierre Gantner
  • Firouze Bani-Sadr
  • Rodolphe Garraffo
  • Pierre-Marie Roger
  • Michèle Treger
  • Thomas Jovelin
  • Pascal Pugliese
  • David Rey
  • Dat’AIDS cohort

Abstract

Objectives: To assess immunovirological response, safety and pharmacokinetic of NRTI-sparing regimen dual therapy of atazanavir (ATV) and raltegravir (RAL) in maintenance strategy. Methods: A retrospective analysis was conducted on a cohort of HIV-infected adults followed in French centers (Dat’AIDS cohort), comparing the proportions of virological and therapeutic failures between ATV + RAL and ATV/ritonavir + RAL dual therapy regimens. Results: 283 patients were assessed: 185 switched for ATV + RAL and 98 for ATV/ritonavir + RAL dual therapy. Virological failure rate at week 96 was 13.8% (95% CI, 9.8–17.8), without difference between the two groups (Log-rank Test, p = 0.87). The cumulative percentages of patients remaining free of therapeutic failure at week 24, 48 and 96 of dual therapy were 74.9% (95% CI, 69.9–80.0), 65.4% (95% CI, 59.8–70.9) and 53.4% (95% CI, 47.5–59.2), respectively. Four out of 39 confirmed virological failures developed RAL resistance. By multivariate analysis, virological failure was associated with high HIV-1 RNA zenith (p = 0.02), low CD4+ T-cell count at baseline (p

Suggested Citation

  • Pierre Gantner & Firouze Bani-Sadr & Rodolphe Garraffo & Pierre-Marie Roger & Michèle Treger & Thomas Jovelin & Pascal Pugliese & David Rey & Dat’AIDS cohort, 2016. "Switch to Ritonavir-Boosted versus Unboosted Atazanavir plus Raltegravir Dual-Drug Therapy Leads to Similar Efficacy and Safety Outcomes in Clinical Practice," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0164240
    DOI: 10.1371/journal.pone.0164240
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    1. Clay Bavinger & Eran Bendavid & Katherine Niehaus & Richard A Olshen & Ingram Olkin & Vandana Sundaram & Nicole Wein & Mark Holodniy & Nanjiang Hou & Douglas K Owens & Manisha Desai, 2013. "Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-14, March.
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    1. Guillemette Quatremère & Marguerite Guiguet & Patricia Girardi & Marie-Noëlle Liaud & Coline Mey & Cynthia Benkhoucha & Franck Barbier & Graciela Cattaneo & Anne Simon & Daniela Rojas Castro, 2017. "How are women living with HIV in France coping with their perceived side effects of antiretroviral therapy? Results from the EVE study," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.

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