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Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium

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  • Haeil Park
  • Xiaoyin Li
  • Yeunjoo E Song
  • Karen Y He
  • Xiaofeng Zhu

Abstract

Meta-analysis of single trait for multiple cohorts has been used for increasing statistical power in genome-wide association studies (GWASs). Although hundreds of variants have been identified by GWAS, these variants only explain a small fraction of phenotypic variation. Cross-phenotype association analysis (CPASSOC) can further improve statistical power by searching for variants that contribute to multiple traits, which is often relevant to pleiotropy. In this study, we performed CPASSOC analysis on the summary statistics from the Genetic Investigation of ANthropometric Traits (GIANT) consortium using a novel method recently developed by our group. Sex-specific meta-analysis data for height, body mass index (BMI), and waist-to-hip ratio adjusted for BMI (WHRadjBMI) from discovery phase of the GIANT consortium study were combined using CPASSOC for each trait as well as 3 traits together. The conventional meta-analysis results from the discovery phase data of GIANT consortium studies were used to compare with that from CPASSOC analysis. The CPASSOC analysis was able to identify 17 loci associated with anthropometric traits that were missed by conventional meta-analysis. Among these loci, 16 have been reported in literature by including additional samples and 1 is novel. We also demonstrated that CPASSOC is able to detect pleiotropic effects when analyzing multiple traits.

Suggested Citation

  • Haeil Park & Xiaoyin Li & Yeunjoo E Song & Karen Y He & Xiaofeng Zhu, 2016. "Multivariate Analysis of Anthropometric Traits Using Summary Statistics of Genome-Wide Association Studies from GIANT Consortium," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-17, October.
    • Handle: RePEc:plo:pone00:0163912
    DOI: 10.1371/journal.pone.0163912
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    References listed on IDEAS

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    1. Sunduimijid Bolormaa & Jennie E Pryce & Antonio Reverter & Yuandan Zhang & William Barendse & Kathryn Kemper & Bruce Tier & Keith Savin & Ben J Hayes & Michael E Goddard, 2014. "A Multi-Trait, Meta-analysis for Detecting Pleiotropic Polymorphisms for Stature, Fatness and Reproduction in Beef Cattle," PLOS Genetics, Public Library of Science, vol. 10(3), pages 1-23, March.
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    Cited by:

    1. Ziyi Xiong & Xingjian Gao & Yan Chen & Zhanying Feng & Siyu Pan & Haojie Lu & Andre G. Uitterlinden & Tamar Nijsten & Arfan Ikram & Fernando Rivadeneira & Mohsen Ghanbari & Yong Wang & Manfred Kayser , 2022. "Combining genome-wide association studies highlight novel loci involved in human facial variation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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