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QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin

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  • Zhanmei Zhou
  • Zheng Hu
  • Mei Li
  • Fengxin Zhu
  • Hao Zhang
  • Jing Nie
  • Jun Ai

Abstract

Chronic kidney disease (CKD) is becoming a worldwide problem. However, current treatment options are limited. In the current study we showed that QiShenYiQi (QSYQ), a water-ethanol extract from several Chinese medicines, is a potent inhibitor of renal interstitial fibrosis. QSYQ inhibited transforming growth factor-β1 (TGF-β1)-responsive α-smooth muscle actin (α-SMA), collagen I, and fibronectin up-regulation in obstructive nephropathy and cultured cells. Administration of QSYQ also inhibited the established renal interstitial fibrosis in obstructive nephropathy. Interestingly, QSYQ selectively inhibited TGF-β1-induced β-catenin up-regulation and downstream gene transcription. Taken together, our study suggests that QSYQ selectively inhibits TGF-β1-induced β-catenin up-regulation and might have significant therapeutic potential for the treatment of renal fibrosis.

Suggested Citation

  • Zhanmei Zhou & Zheng Hu & Mei Li & Fengxin Zhu & Hao Zhang & Jing Nie & Jun Ai, 2016. "QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-18, September.
  • Handle: RePEc:plo:pone00:0162873
    DOI: 10.1371/journal.pone.0162873
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    1. Carl-Henrik Heldin & Kohei Miyazono & Peter ten Dijke, 1997. "TGF-β signalling from cell membrane to nucleus through SMAD proteins," Nature, Nature, vol. 390(6659), pages 465-471, December.
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