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Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes

Author

Listed:
  • Alvaro Velazquez-Villoria
  • Sergio Recalde
  • Jaouad Anter
  • Jaione Bezunartea
  • Maria Hernandez-Sanchez
  • Laura García-García
  • Elena Alonso
  • Jose María Ruiz-Moreno
  • Javier Araiz-Iribarren
  • Patricia Fernandez-Robredo
  • Alfredo García-Layana

Abstract

Choroidal neovascularization (CNV) commonly occurs in age related macular degeneration and pathological myopia patients. In this study we conducted a case-control prospective study including 431 participants. The aim of this study was to determine the potential association between 10 single nucleotide polymorphisms (SNPs) located in 4 different genetic regions (CFI, COL8A1, LIPC, and APOE), and choroidal neovascularization in age-related macular degeneration and the development of choroidal neovascularization in highly myopic eyes of a Caucasian population. Univariate and multivariate logistic regression analysis adjusted for age, sex and hypertension was performed for each allele, genotype and haplotype frequency analysis. We found that in the univariate analysis that both single-nucleotide polymorphisms in COL8A1 gene (rs13095226 and rs669676) together with age, sex and hypertension were significantly associated with myopic CNV development in Spanish patients (p 0.05); however, analysis of the axial length between genotypes of rs13095226 revealed an important influence of COL8A1 in the development of CNV in high myopia. Furthermore we conducted a meta-analysis of COL8A1, CFI and LIPC genes SNPs (rs669676, rs10033900 and rs10468017) and found that only rs669676 of these SNPs were associated with high myopia neovascularization.

Suggested Citation

  • Alvaro Velazquez-Villoria & Sergio Recalde & Jaouad Anter & Jaione Bezunartea & Maria Hernandez-Sanchez & Laura García-García & Elena Alonso & Jose María Ruiz-Moreno & Javier Araiz-Iribarren & Patrici, 2016. "Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-17, September.
    • Handle: RePEc:plo:pone00:0162296
    DOI: 10.1371/journal.pone.0162296
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    References listed on IDEAS

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    1. Johanna M Seddon & Robyn Reynolds & Yi Yu & Bernard Rosner, 2014. "Three New Genetic Loci (R1210C in CFH, Variants in COL8A1 and RAD51B) Are Independently Related to Progression to Advanced Macular Degeneration," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-11, January.
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