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Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

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  • Danian Dai
  • Bo Chen
  • Hailin Tang
  • Bin Wang
  • Zhiping Zhao
  • Xiaoming Xie
  • Weidong Wei

Abstract

Previous studies have indicated that carcinoembryonic antigen (CEA) and cancer antigen 15–3 (CA15-3) levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer (TNBC) remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I–IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival (OS) and disease-free survival (DFS) rates than those in the low-level groups (p

Suggested Citation

  • Danian Dai & Bo Chen & Hailin Tang & Bin Wang & Zhiping Zhao & Xiaoming Xie & Weidong Wei, 2016. "Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-16, August.
    • Handle: RePEc:plo:pone00:0161902
    DOI: 10.1371/journal.pone.0161902
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    1. Yingbo Shao & Xianfu Sun & Yaning He & Chaojun Liu & Hui Liu, 2015. "Elevated Levels of Serum Tumor Markers CEA and CA15-3 Are Prognostic Parameters for Different Molecular Subtypes of Breast Cancer," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-11, July.
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