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Prevalence and Prognostic Significance of Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination (ACE) 2 Study

Author

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  • Jacob A Winther
  • Jon Brynildsen
  • Arne Didrik Høiseth
  • Ivar Følling
  • Pål H Brekke
  • Geir Christensen
  • Tor-Arne Hagve
  • Joseph G Verbalis
  • Torbjørn Omland
  • Helge Røsjø

Abstract

Background: Hyponatremia is prevalent and associated with mortality in patients with heart failure (HF). The prevalence and prognostic implications of hyponatremia in acute exacerbation of chronic obstructive pulmonary (AECOPD) have not been established. Method: We included 313 unselected patients with acute dyspnea who were categorized by etiology of dyspnea according to established guidelines (derivation cohort). Serum Na+ was determined on hospital admission and corrected for hyperglycemia, and hyponatremia was defined as [Na+]

Suggested Citation

  • Jacob A Winther & Jon Brynildsen & Arne Didrik Høiseth & Ivar Følling & Pål H Brekke & Geir Christensen & Tor-Arne Hagve & Joseph G Verbalis & Torbjørn Omland & Helge Røsjø, 2016. "Prevalence and Prognostic Significance of Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination (ACE) 2 Study," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0161232
    DOI: 10.1371/journal.pone.0161232
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