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Altered Immune Profiles of Natural Killer Cells in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

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  • Qiong-Fang Zhang
  • Jian-Ying Shao
  • Wen-Wei Yin
  • Yang Xia
  • Ling Chen
  • Xing Wang
  • Huai-Dong Hu
  • Peng Hu
  • Hong Ren
  • Da-Zhi Zhang

Abstract

Background: Natural killer (NK) cells are the main effective component of the innate immune system that responds to chronic hepatitis B (CHB) infection. Although numerous studies have reported the immune profiles of NK cells in CHB patients, they are limited by inconsistent results. Thus, we performed a meta-analysis to characterize reliably the immune profiles of NK cells after CHB infection, specifically frequency, phenotype, and function. Methods: A literature search of the computer databases MEDLINE, PUBMED, EMBASE, and Cochrane Center Register of Controlled Trails was performed and 19 studies were selected. The standard mean difference (SMD) and 95% confidence interval (CI) of each continuous variable was estimated with a fixed effects model when I2

Suggested Citation

  • Qiong-Fang Zhang & Jian-Ying Shao & Wen-Wei Yin & Yang Xia & Ling Chen & Xing Wang & Huai-Dong Hu & Peng Hu & Hong Ren & Da-Zhi Zhang, 2016. "Altered Immune Profiles of Natural Killer Cells in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-16, August.
    • Handle: RePEc:plo:pone00:0160171
    DOI: 10.1371/journal.pone.0160171
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    1. Ofer Mandelboim & Niva Lieberman & Marianna Lev & Lada Paul & Tal I. Arnon & Yuri Bushkin & Daniel M. Davis & Jack L. Strominger & Jonathan W. Yewdell & Angel Porgador, 2001. "Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells," Nature, Nature, vol. 409(6823), pages 1055-1060, February.
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