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The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis

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  • Kun Ji
  • Mingxuan Zhang
  • Qi Chu
  • Yong Gan
  • Hui Ren
  • Liyan Zhang
  • Liwei Wang
  • Xiaoxiu Li
  • Wei Wang

Abstract

Objective: High expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has been detected in a variety of human tumors. However, the association of positive p-STAT3 expression with clinicopathological parameters and the prognosis of colorectal cancer patients remain controversial. To identify the relationship between p-STAT3 expression and clinicopathological parameters and prognosis in patients with colorectal cancer, a systematic review and meta-analysis were performed. Methods: We performed a comprehensive literature search from PubMed, EMBASE, and SinoMed through 27 March, 2016. Hazard ratios (HRs) with 95% confidence intervals (CI) were combined to evaluate the association between p-STAT3 expression and overall survival of colorectal cancer patients. Odds ratios (ORs) with 95% CI were combined to evaluate the association between p-STAT3 expression and clinicopathological parameters in patients with colorectal cancer. Results: Seventeen studies including a total of 2,346 colorectal cancer patients were included in this meta-analysis. The combined HR was 1.43 (95% CI: 1.23–1.67, P

Suggested Citation

  • Kun Ji & Mingxuan Zhang & Qi Chu & Yong Gan & Hui Ren & Liyan Zhang & Liwei Wang & Xiaoxiu Li & Wei Wang, 2016. "The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-16, August.
    • Handle: RePEc:plo:pone00:0160125
    DOI: 10.1371/journal.pone.0160125
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    Cited by:

    1. Mengting Tong & Jing Wang & Nanyu Jiang & Hongming Pan & Da Li, 2017. "Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-13, August.

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