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A Cross-Sectional Study of Ageing and Cardiovascular Function over the Baboon Lifespan

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  • Kristen R Yeung
  • Christine L Chiu
  • Suzanne Pears
  • Scott J Heffernan
  • Angela Makris
  • Annemarie Hennessy
  • Joanne M Lind

Abstract

Background: Ageing is associated with changes at the molecular and cellular level that can alter cardiovascular function and ultimately lead to disease. The baboon is an ideal model for studying ageing due to the similarities in genetic, anatomical, physiological and biochemical characteristics with humans. The aim of this cross-sectional study was to investigate the changes in cardiovascular profile of baboons over the course of their lifespan. Methods: Data were collected from 109 healthy baboons (Papio hamadryas) at the Australian National Baboon Colony. A linear regression model, adjusting for sex, was used to analyse the association between age and markers of ageing with P 12 years) had significantly shorter telomeres when compared to younger (

Suggested Citation

  • Kristen R Yeung & Christine L Chiu & Suzanne Pears & Scott J Heffernan & Angela Makris & Annemarie Hennessy & Joanne M Lind, 2016. "A Cross-Sectional Study of Ageing and Cardiovascular Function over the Baboon Lifespan," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0159576
    DOI: 10.1371/journal.pone.0159576
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    References listed on IDEAS

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    1. Elizabeth H. Blackburn, 2000. "Telomere states and cell fates," Nature, Nature, vol. 408(6808), pages 53-56, November.
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