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Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis

Author

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  • Anders A Bengtsson
  • Johan Trygg
  • Dirk M Wuttge
  • Gunnar Sturfelt
  • Elke Theander
  • Magdalena Donten
  • Thomas Moritz
  • Carl-Johan Sennbro
  • Frida Torell
  • Christian Lood
  • Izabella Surowiec
  • Stefan Rännar
  • Torbjörn Lundstedt

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect most organ systems including skin, joints and the kidney. Clinically, SLE is a heterogeneous disease and shares features of several other rheumatic diseases, in particular primary Sjögrens syndrome (pSS) and systemic sclerosis (SSc), why it is difficult to diagnose The pathogenesis of SLE is not completely understood, partly due to the heterogeneity of the disease. This study demonstrates that metabolomics can be used as a tool for improved diagnosis of SLE compared to other similar autoimmune diseases. We observed differences in metabolic profiles with a classification specificity above 67% in the comparison of SLE with pSS, SSc and a matched group of healthy individuals. Selected metabolites were also significantly different between studied diseases. Biochemical pathway analysis was conducted to gain understanding of underlying pathways involved in the SLE pathogenesis. We found an increased oxidative activity in SLE, supported by increased xanthine oxidase activity and an increased turnover in the urea cycle. The most discriminatory metabolite observed was tryptophan, with decreased levels in SLE patients compared to control groups. Changes of tryptophan levels were related to changes in the activity of the aromatic amino acid decarboxylase (AADC) and/or to activation of the kynurenine pathway.

Suggested Citation

  • Anders A Bengtsson & Johan Trygg & Dirk M Wuttge & Gunnar Sturfelt & Elke Theander & Magdalena Donten & Thomas Moritz & Carl-Johan Sennbro & Frida Torell & Christian Lood & Izabella Surowiec & Stefan , 2016. "Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-15, July.
  • Handle: RePEc:plo:pone00:0159384
    DOI: 10.1371/journal.pone.0159384
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    References listed on IDEAS

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    1. Rasmus Madsen & Viqar Showkat Banday & Thomas Moritz & Johan Trygg & Kristina Lejon, 2012. "Altered Metabolic Signature in Pre-Diabetic NOD Mice," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-9, April.
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    1. Nick Huang & Thomas Winans & Brandon Wyman & Zachary Oaks & Tamas Faludi & Gourav Choudhary & Zhi-Wei Lai & Joshua Lewis & Miguel Beckford & Manuel Duarte & Daniel Krakko & Akshay Patel & Joy Park & T, 2024. "Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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