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Efficacy and Safety of OnabotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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  • Tao Cheng
  • Wei-bing Shuang
  • Dong-dong Jia
  • Min Zhang
  • Xu-nan Tong
  • Wei-dong Yang
  • Xu-ming Jia
  • Shuo Li

Abstract

Background: Neurogenic detrusor overactivity (NDO) affects the quality of life (QoL) of millions of individuals worldwide. The purpose of this study was to assess the efficacy and safety of onabotulinumtoxinA in patients with NDO using a network meta-analytic approach, which can also quantify and compare the efficacy of onabotulinumtoxinA across different dosages. Methods: PubMed, EMBASE, and the Controlled Trials Register were searched to identify randomized controlled trials comparing onabotulinumtoxinA to a control for NDO in adult patients. The primary outcome was the mean number of urinary incontinence (UI) episodes per week. Urodynamic parameters included the maximum cystometric capacity (MCC) and the maximum detrusor pressure (MDP). The safety of onabotulinumtoxinA was determined by the incidence of various frequent adverse events (AEs). Two authors extracted data independently, and the statistical analyses were performed using RevMan 5.1.0 software. Results: A total of 1,915 patients from six randomized controlled trials were included in this meta-analysis. The onabotulinumtoxinA-treated groups had a significantly decreased mean number of urinary incontinence episodes per week (at week 6) (onabotulinumtoxinA200U: MD: -10.72, 95% CI: -13.4 to -8.04, P

Suggested Citation

  • Tao Cheng & Wei-bing Shuang & Dong-dong Jia & Min Zhang & Xu-nan Tong & Wei-dong Yang & Xu-ming Jia & Shuo Li, 2016. "Efficacy and Safety of OnabotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0159307
    DOI: 10.1371/journal.pone.0159307
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    1. Thomas M Kessler & Lucas M Bachmann & Christoph Minder & David Löhrer & Martin Umbehr & Holger J Schünemann & Alfons G H Kessels, 2011. "Adverse Event Assessment of Antimuscarinics for Treating Overactive Bladder: A Network Meta-Analytic Approach," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-1, February.
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