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AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials

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  • Graham M Wheeler
  • Michael J Sweeting
  • Adrian P Mander

Abstract

In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.

Suggested Citation

  • Graham M Wheeler & Michael J Sweeting & Adrian P Mander, 2016. "AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-17, July.
    • Handle: RePEc:plo:pone00:0159026
    DOI: 10.1371/journal.pone.0159026
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    References listed on IDEAS

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    1. Reiner, Ethan & Paoletti, Xavier & O'Quigley, John, 1999. "Operating characteristics of the standard phase I clinical trial design," Computational Statistics & Data Analysis, Elsevier, vol. 30(3), pages 303-315, May.
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