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Ultrasensitive HCV RNA Quantification in Antiviral Triple Therapy: New Insight on Viral Clearance Dynamics and Treatment Outcome Predictors

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Listed:
  • Anna Rosa Garbuglia
  • Ubaldo Visco-Comandini
  • Raffaella Lionetti
  • Daniele Lapa
  • Filippo Castiglione
  • Gianpiero D’Offizi
  • Chiara Taibi
  • Marzia Montalbano
  • Maria Rosaria Capobianchi
  • Paola Paci

Abstract

Objectives: Identifying the predictive factors of Sustained Virological Response (SVR) represents an important challenge in new interferon-based DAA therapies. Here, we analyzed the kinetics of antiviral response associated with a triple drug regimen, and the association between negative residual viral load at different time points during treatment. Methods: Twenty-three HCV genotype 1 (GT 1a n = 11; GT1b n = 12) infected patients were included in the study. Linear Discriminant Analysis (LDA) was used to establish possible association between HCV RNA values at days 1 and 4 from start of therapy and SVR. Principal component analysis (PCA) was applied to analyze the correlation between HCV RNA slope and SVR. A ultrasensitive (US) method was established to measure the residual HCV viral load in those samples which resulted “detected

Suggested Citation

  • Anna Rosa Garbuglia & Ubaldo Visco-Comandini & Raffaella Lionetti & Daniele Lapa & Filippo Castiglione & Gianpiero D’Offizi & Chiara Taibi & Marzia Montalbano & Maria Rosaria Capobianchi & Paola Paci, 2016. "Ultrasensitive HCV RNA Quantification in Antiviral Triple Therapy: New Insight on Viral Clearance Dynamics and Treatment Outcome Predictors," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-15, August.
    • Handle: RePEc:plo:pone00:0158989
    DOI: 10.1371/journal.pone.0158989
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