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Toward a More Efficient Implementation of Antifibrillation Pacing

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  • Dan Wilson
  • Jeff Moehlis

Abstract

We devise a methodology to determine an optimal pattern of inputs to synchronize firing patterns of cardiac cells which only requires the ability to measure action potential durations in individual cells. In numerical bidomain simulations, the resulting synchronizing inputs are shown to terminate spiral waves with a higher probability than comparable inputs that do not synchronize the cells as strongly. These results suggest that designing stimuli which promote synchronization in cardiac tissue could improve the success rate of defibrillation, and point towards novel strategies for optimizing antifibrillation pacing.

Suggested Citation

  • Dan Wilson & Jeff Moehlis, 2016. "Toward a More Efficient Implementation of Antifibrillation Pacing," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-28, July.
    • Handle: RePEc:plo:pone00:0158239
    DOI: 10.1371/journal.pone.0158239
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