IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0158182.html
   My bibliography  Save this article

Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

Author

Listed:
  • Céline Renoux
  • Marc Romana
  • Philippe Joly
  • Séverine Ferdinand
  • Camille Faes
  • Nathalie Lemonne
  • Sarah Skinner
  • Nathalie Garnier
  • Maryse Etienne-Julan
  • Yves Bertrand
  • Marie Petras
  • Giovanna Cannas
  • Lydia Divialle-Doumdo
  • Elie Nader
  • Daniela Cuzzubbo
  • Yann Lamarre
  • Alexandra Gauthier
  • Xavier Waltz
  • Kamila Kebaili
  • Cyril Martin
  • Arnaud Hot
  • Marie-Dominique Hardy-Dessources
  • Vincent Pialoux
  • Philippe Connes

Abstract

Objectives: Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown. Materials and Methods: Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients. Results: Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age. Conclusion: The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders.

Suggested Citation

  • Céline Renoux & Marc Romana & Philippe Joly & Séverine Ferdinand & Camille Faes & Nathalie Lemonne & Sarah Skinner & Nathalie Garnier & Maryse Etienne-Julan & Yves Bertrand & Marie Petras & Giovanna C, 2016. "Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0158182
    DOI: 10.1371/journal.pone.0158182
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158182
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0158182&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0158182?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kizzy-Clara Cita & Laurent Brureau & Nathalie Lemonne & Marie Billaud & Philippe Connes & Séverine Ferdinand & Benoit Tressières & Vanessa Tarer & Maryse Etienne-Julan & Pascal Blanchet & Jacques Elio, 2016. "Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-10, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0158182. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.