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Effects of Pitavastatin on Lipid Profiles in HIV-Infected Patients with Dyslipidemia and Receiving Atazanavir/Ritonavir: A Randomized, Double-Blind, Crossover Study

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  • Asita Wongprikorn
  • Chonlaphat Sukasem
  • Apichaya Puangpetch
  • Pawin Numthavej
  • Ammarin Thakkinstian
  • Sasisopin Kiertiburanakul

Abstract

Background: Dyslipidemia as a risk factor of cardiovascular disease is common especially in HIV-infected patients who are using protease inhibitors (PIs) including atazanavir. Pitavastatin has less drug-drug interactions and demonstrable efficacy in decreasing lipid levels in non HIV-infected individuals. Materials and Methods: This study was a randomized, double-blind, crossover study comparing the safety and efficacy of pitavastatin vs placebo in HIV-infected patients with dyslipidemia and receiving atazanavir/ritonavir (ATV/r). Patients were randomized to receive either placebo or pitavastatin for 12 weeks. The follow-up visits were every 4 weeks until the end of the study. Results: A total of 12 HIV-infected patients were enrolled to each study group. Of all, 14 (58%) patients were men and mean (standard deviation, SD) age was 48.1 (1.8) years. At 12 weeks of treatment with pitavastatin compared to placebo; mean [95% confidence interval (CI)] total cholesterol (TC) was 207 (187.3, 226.8) mg/dL vs 246.3 (226.5, 266) mg/dL (p

Suggested Citation

  • Asita Wongprikorn & Chonlaphat Sukasem & Apichaya Puangpetch & Pawin Numthavej & Ammarin Thakkinstian & Sasisopin Kiertiburanakul, 2016. "Effects of Pitavastatin on Lipid Profiles in HIV-Infected Patients with Dyslipidemia and Receiving Atazanavir/Ritonavir: A Randomized, Double-Blind, Crossover Study," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-9, June.
    • Handle: RePEc:plo:pone00:0157531
    DOI: 10.1371/journal.pone.0157531
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