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Mediating and Moderating Role of Depression, Conduct Disorder or Attention-Deficit/Hyperactivity Disorder in Developing Adolescent Substance Use Disorders: A Population-Based Study

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  • Kouichi Yoshimasu
  • William J Barbaresi
  • Robert C Colligan
  • Robert G Voigt
  • Amy L Weaver
  • Slavica K Katusic

Abstract

Objective: To evaluate the mediating/moderating effects of common internalizing /externalizing disorders on the association between ADHD and adolescent substance use disorders (SUD) in a population-based birth cohort. Methods: Among 5718 children in the birth cohort, 343 ADHD incident cases and 712 matched controls were identified. Psychiatric diagnoses prior to age 19 were classified into DSM-IV categories. The association between ADHD and SUD was summarized (hazard ratios (HR), 95% CI). The effect of depression, CD/ODD, anxiety was evaluated separately. Results: Assessment of the joint effects of ADHD and each psychiatric disorder did not support a moderating effect of these disorders on SUD on additive scale. However, the association between ADHD and SUD was partially explained by a mediating role of these psychiatric disorders. Conclusion: For clinicians our results emphasize that depression (or CD/ODD) confers greater risk for SUD than ADHD alone. Early detection/treatment of SUD among adolescents with depression (or CD/ODD) is crucial regardless of ADHD.

Suggested Citation

  • Kouichi Yoshimasu & William J Barbaresi & Robert C Colligan & Robert G Voigt & Amy L Weaver & Slavica K Katusic, 2016. "Mediating and Moderating Role of Depression, Conduct Disorder or Attention-Deficit/Hyperactivity Disorder in Developing Adolescent Substance Use Disorders: A Population-Based Study," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0157488
    DOI: 10.1371/journal.pone.0157488
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