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Increased Biological Effective Dose of Radiation Correlates with Prolonged Survival of Patients with Limited-Stage Small Cell Lung Cancer: A Systematic Review

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  • Lucheng Zhu
  • Shirong Zhang
  • Xiao Xu
  • Bing Wang
  • Kan Wu
  • Qinghua Deng
  • Bing Xia
  • Shenglin Ma

Abstract

Objective: Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell lung cancer (LS-SCLC). However, the optimal radiation dose/fractionation remains elusive. This study reviewed current evidence and explored the dose-response relationship in patients with LS-SCLC who were treated with radiochemotherapy. Materials and Methods: A quantitative analysis was performed through a systematic search of PubMed, Web of Science, and the Cochrane Library. The correlations between the biological effective dose (BED) and median overall survival (mOS), median progression-free survival (mPFS), 1-, 3-, and 5-year overall survival (OS) as well as local relapse (LR) were evaluated. Results: In all, 2389 patients in 19 trials were included in this study. Among these 19 trials, seven were conducted in Europe, eight were conducted in Asia and four were conducted in the United States. The 19 trials that were included consisted of 29 arms with 24 concurrent and 5 sequential TRT arms. For all included studies, the results showed that a higher BED prolonged the mOS (R2 = 0.198, p

Suggested Citation

  • Lucheng Zhu & Shirong Zhang & Xiao Xu & Bing Wang & Kan Wu & Qinghua Deng & Bing Xia & Shenglin Ma, 2016. "Increased Biological Effective Dose of Radiation Correlates with Prolonged Survival of Patients with Limited-Stage Small Cell Lung Cancer: A Systematic Review," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0156494
    DOI: 10.1371/journal.pone.0156494
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