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Predictive Factors of Lapatinib and Capecitabine Activity in Patients with HER2-Positive, Trastuzumab-Resistant Metastatic Breast Cancer: Results from the Italian Retrospective Multicenter HERLAPAC Study

Author

Listed:
  • Stefania Gori
  • Alessandro Inno
  • Valentina Rossi
  • Monica Turazza
  • Elena Fiorio
  • Alessandra Fabi
  • Giancarlo Bisagni
  • Jennifer Foglietta
  • Daniele Santini
  • Ida Pavese
  • Arianna Pellegrino
  • Alberto Zambelli
  • Patrizia Vici
  • Vita Leonardi
  • Sandro Barni
  • Silvana Saracchini
  • Giuseppe Bogina
  • Fabiana Marchetti
  • Simona Duranti
  • Gianluigi Lunardi
  • Filippo Montemurro

Abstract

Background: There are no validated predictive markers for lapatinib and capecitabine in patients with trastuzumab-resistant HER2 positive metastatic breast cancer. Methods: Data of 148 consecutive patients treated with lapatinib and capecitabine from March 2007 to December 2013 were collected from 13 Italian institutions. Estimates of progression-free survival (PFS) and overall survival (OS) were obtained with the Kaplan-Meier method and compared with logrank test. The association of clinicopathological variables and the outcome was studied by binary logistic regression analysis and Cox proportional hazard analysis. Results: At a median follow-up of 41 months, median PFS and OS were 7 and 21 months, respectively. Patents with a PFS longer than 7 months had a significantly longer OS, compared with patients with a PFS equal to or shorter than 7 months (36 vs 15 months; p

Suggested Citation

  • Stefania Gori & Alessandro Inno & Valentina Rossi & Monica Turazza & Elena Fiorio & Alessandra Fabi & Giancarlo Bisagni & Jennifer Foglietta & Daniele Santini & Ida Pavese & Arianna Pellegrino & Alber, 2016. "Predictive Factors of Lapatinib and Capecitabine Activity in Patients with HER2-Positive, Trastuzumab-Resistant Metastatic Breast Cancer: Results from the Italian Retrospective Multicenter HERLAPAC St," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0156221
    DOI: 10.1371/journal.pone.0156221
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