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Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study

Author

Listed:
  • Vitaly Smelov
  • Tarik Gheit
  • Karin Sundström
  • Alexander Ploner
  • Sandrine McKay-Chopin
  • Carina Eklund
  • Massimo Tommasino
  • Joakim Dillner

Abstract

Background: A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited. Methods: A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay. Results: Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively. Conclusions: A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection. Impact: C. trachomatis appears not to be involved in cervical adenocarcinomas.

Suggested Citation

  • Vitaly Smelov & Tarik Gheit & Karin Sundström & Alexander Ploner & Sandrine McKay-Chopin & Carina Eklund & Massimo Tommasino & Joakim Dillner, 2016. "Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-5, May.
    • Handle: RePEc:plo:pone00:0156215
    DOI: 10.1371/journal.pone.0156215
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