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Diagnostic Performance of Indocyanine Green-Guided Sentinel Lymph Node Biopsy in Breast Cancer: A Meta-Analysis

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  • Xiaohui Zhang
  • Yan Li
  • Yidong Zhou
  • Feng Mao
  • Yan Lin
  • Jinghong Guan
  • Qiang Sun

Abstract

Background: The diagnostic performance of indocyanine green (ICG) fluorescence-guided sentinel lymph node biopsy (SLNB) for the presence of metastases in breast cancer remains unclear. Objective: We performed a meta-analysis to investigate the diagnostic performance of ICG-guided SLNB. Methods: Eligible studies were identified from searches of the databases PubMed and EMBASE up to September 2015. Studies that reported the detection rate of ICG fluorescence-guided SLNB with full axillary lymph node dissection and histological or immunohistochemical examinations were included. A meta-analysis was performed to generate pooled detection rate, sensitivity, specificity, false negative rate, diagnostic odds ratio (DOR) and a summary receiver operator characteristic curve (SROC). Results: Nineteen published studies were included to generate a pooled detection rate, comprising 2594 patients. The pooled detection rate was 0.98 (95% confidence interval [CI], 0.96–0.99). Six studies finally met the criteria for meta-analysis, which yielded a pooled sensitivity of 0.92 (95% CI, 0.85–0.96), specificity 1 (95% CI, 0.97–1), and DOR 311.47 (95% CI, 84.11–1153.39). The area under the SROC was 0.9758. No publication bias was found. Conclusion: ICG fluorescence-guided SLNB is viable for detection of lymph node metastases in breast cancer. Large-scale randomized multi-center trials are necessary to confirm our results.

Suggested Citation

  • Xiaohui Zhang & Yan Li & Yidong Zhou & Feng Mao & Yan Lin & Jinghong Guan & Qiang Sun, 2016. "Diagnostic Performance of Indocyanine Green-Guided Sentinel Lymph Node Biopsy in Breast Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0155597
    DOI: 10.1371/journal.pone.0155597
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