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An Indirect Comparison of Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate and Abacavir/Lamivudine + Dolutegravir in Initial Therapy

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  • Josep M. Llibre
  • François Raffi
  • Graeme Moyle
  • Georg Behrens
  • Stephane Bouee
  • Geraldine Reilly
  • Peter Borg
  • David Piontkowsky
  • Felipe Rogatto

Abstract

Objectives: The objective of this analysis is to perform an indirect comparison of elvitegravir, cobicistat, emtricitabine and tenofovir DF (E/C/F/TDF) to abacavir/lamivudine and dolutegravir (ABC/3TC + DTG) by using 2 trials evaluating each of these regimens in comparison to efavirenz, emtricitabine and tenofovir DF (EFV/FTC/TDF). Methods: An indirect comparison was performed by using a generalization of Bucher's methodology to calculate risk differences. Two phase III clinical trials (GS-US-236-0102 and SINGLE—described above) were used. Results: Results of the indirect comparison showed no statistically significant risk difference of the efficacy endpoint of achieving HIV RNA

Suggested Citation

  • Josep M. Llibre & François Raffi & Graeme Moyle & Georg Behrens & Stephane Bouee & Geraldine Reilly & Peter Borg & David Piontkowsky & Felipe Rogatto, 2016. "An Indirect Comparison of Efficacy and Safety of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate and Abacavir/Lamivudine + Dolutegravir in Initial Therapy," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0155406
    DOI: 10.1371/journal.pone.0155406
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    References listed on IDEAS

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    1. Dipen A Patel & Sonya J Snedecor & Wing Yu Tang & Lavanya Sudharshan & Jessica W Lim & Robert Cuffe & Sonia Pulgar & Kim A Gilchrist & Rodrigo Refoios Camejo & Jennifer Stephens & Garrett Nichols, 2014. "48-Week Efficacy and Safety of Dolutegravir Relative to Commonly Used Third Agents in Treatment-Naive HIV-1–Infected Patients: A Systematic Review and Network Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-10, September.
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