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Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility

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  • Ida G Fostad
  • Jon R Eidet
  • Tor P Utheim
  • Sten Ræder
  • Neil S Lagali
  • Edvard B Messelt
  • Darlene A Dartt

Abstract

The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies were consecutively included in the study. The patients underwent a comprehensive ophthalmological work-up and completed self-questionnaires on symptoms of ocular dryness (Ocular Surface Disease Index [OSDI] and McMonnies Dry Eye Questionnaire) and the Sjögren’s syndrome (SS) questionnaire (SSQ). Three hundred and eighteen patients (52% women and 48% men) with DED were included. Patient demographics were: 0 to 19 years (1%), 20 to 39 (25%), 40 to 59 (34%), 60 to 79 (35%) and 80 to 99 (5%). Xerostomia, defined as “daily symptoms of dry mouth the last three months” (as presented in SSQ) was reported by 23% of the patients. Female sex was more common among patients with xerostomia (81%) than among non-xerostomia patients (44%; P

Suggested Citation

  • Ida G Fostad & Jon R Eidet & Tor P Utheim & Sten Ræder & Neil S Lagali & Edvard B Messelt & Darlene A Dartt, 2016. "Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0155214
    DOI: 10.1371/journal.pone.0155214
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