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Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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  • Xingxing Ren
  • Zengai Chen
  • Shuang Zheng
  • Tingting Han
  • Yangxue Li
  • Wei Liu
  • Yaomin Hu

Abstract

Objectives: To explore the association between the triglyceride to HDL-C ratio (TG/HDL-C) and insulin resistance in Chinese patients with newly diagnosed type 2 diabetes mellitus. Methods: Patients with newly diagnosed type 2 diabetes mellitus (272 men and 288 women) were enrolled and divided into three groups according to TG/HDL-C tertiles. Insulin resistance was defined by homeostatic model assessment of insulin resistance (HOMA-IR). Demographic information and clinical characteristics were obtained. Spearman’s correlation was used to estimate the association between TG/HDL-C and other variables. Multiple logistic regression analyses were adopted to obtain probabilities of insulin resistance. A receiver operating characteristic analysis was conducted to evaluate the ability of TG/HDL-C to discriminate insulin resistance. Results: TG/HDL-C was associated with insulin resistance in Chinese patients with newly diagnosed T2DM (Spearman’s correlation coefficient = 0.21, P

Suggested Citation

  • Xingxing Ren & Zengai Chen & Shuang Zheng & Tingting Han & Yangxue Li & Wei Liu & Yaomin Hu, 2016. "Association between Triglyceride to HDL-C Ratio (TG/HDL-C) and Insulin Resistance in Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0154345
    DOI: 10.1371/journal.pone.0154345
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