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Stem Cell Therapy for Diabetic Erectile Dysfunction in Rats: A Meta-Analysis

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  • Mingchao Li
  • Hao Li
  • Yajun Ruan
  • Tao Wang
  • Jihong Liu

Abstract

Introduction: Stem cell therapy is a novel method for the treatment of diabetic erectile dysfunction (ED). Many relative animal studies have been done to evaluate the efficacy of this therapy in rats. Aims: This meta-analysis was performed to compare the efficacy of different stem cell therapies, to evaluate the influential factors and to determine the optimal stem cell therapeutic strategy for diabetic ED. Methods: We searched the studies analyzing the efficacy of stem cell therapy for diabetic ED in rats published before September 30, 2015 in PubMed, Web of Science and EBSCO. A random effects meta-analysis was conducted to assess the outcomes of stem cell therapy. Subgroup analysis was also performed by separating these studies based on their different characteristics. Changes in the ratio of intracavernous pressure (ICP) to mean arterial pressure (MAP) and in the structure of the cavernous body were compared. Results: 10 studies with 302 rats were enrolled in this meta-analysis. Pooled analysis of these studies showed a beneficial effect of stem cell therapy in improving erectile function of diabetic rats (SMD 4.03, 95% CI = 3.22 to 4.84, P

Suggested Citation

  • Mingchao Li & Hao Li & Yajun Ruan & Tao Wang & Jihong Liu, 2016. "Stem Cell Therapy for Diabetic Erectile Dysfunction in Rats: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0154341
    DOI: 10.1371/journal.pone.0154341
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    References listed on IDEAS

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    1. Haitao Shan & Fengzhi Chen & Tao Zhang & Shuhua He & Le Xu & Anyang Wei, 2015. "Stem Cell Therapy for Erectile Dysfunction of Cavernous Nerve Injury Rats: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-23, April.
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