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Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease

Author

Listed:
  • Minoru Kanaya
  • Kazuko Shibuya
  • Rei Hirochika
  • Miyoko Kanemoto
  • Kazuteru Ohashi
  • Masafumi Okada
  • Yukiko Wagatsuma
  • Yukiko Cho
  • Hiroshi Kojima
  • Takanori Teshima
  • Masahiro Imamura
  • Hisashi Sakamaki
  • Akira Shibuya

Abstract

Acute graft-versus-host disease (aGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because diagnosis of aGVHD is exclusively based on clinical symptoms and pathological findings, reliable and noninvasive laboratory tests for accurate diagnosis are required. An activating immunoreceptor, DNAM-1 (CD226), is expressed on T cells and natural killer cells and is involved in the development of aGVHD. Here, we identified a soluble form of DNAM-1 (sDNAM-1) in human sera. In retrospective univariate and multivariate analyses of allo-HSCT patients (n = 71) at a single center, cumulative incidences of all grade (grade I–IV) and sgrade II–IV aGVHD in patients with high maximal serum levels of sDNAM-1 (≥30 pM) in the 7 days before allo-HSCT were significantly higher than those in patients with low maximal serum levels of sDNAM-1 (

Suggested Citation

  • Minoru Kanaya & Kazuko Shibuya & Rei Hirochika & Miyoko Kanemoto & Kazuteru Ohashi & Masafumi Okada & Yukiko Wagatsuma & Yukiko Cho & Hiroshi Kojima & Takanori Teshima & Masahiro Imamura & Hisashi Sak, 2016. "Soluble DNAM-1, as a Predictive Biomarker for Acute Graft-Versus-Host Disease," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0154173
    DOI: 10.1371/journal.pone.0154173
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