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Fine Mapping of the Body Fat QTL on Human Chromosome 1q43

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  • Brahim Aissani
  • Howard W Wiener
  • Kui Zhang

Abstract

Introduction: Evidence for linkage and association of obesity-related quantitative traits to chromosome 1q43 has been reported in the Quebec Family Study (QFS) and in populations of Caribbean Hispanic ancestries yet no specific candidate locus has been replicated to date. Methods: Using a set of 1,902 single nucleotide polymorphisms (SNPs) genotyped in 525 African American (AA) and 391 European American (EA) women enrolled in the NIEHS uterine fibroid study (NIEHS-UFS), we generated a fine association map for the body mass index (BMI) across a 2.3 megabase-long interval delimited by RGS7 (regulator of G-protein signaling 7) and PLD5 (Phospholipase D, member 5). Multivariable-adjusted linear regression models were fitted to the data to evaluate the association in race-stratified analyses and meta-analysis. Results: The strongest associations were observed in a recessive genetic model and peaked in the 3’ end of RGS7 at intronic rs261802 variant in the AA group (p = 1.0 x 10−4) and in meta-analysis of AA and EA samples (p = 9.0 x 10−5). In the EA group, moderate associations peaked at rs6429264 (p = 2.0 x 10−3) in the 2 Kb upstream sequence of RGS7. In the reference populations for the European ancestry in the 1,000 genomes project, rs6429264 occurs in strong linkage disequilibrium (D’ = 0.94) with rs1341467, the strongest candidate SNP for total body fat in QFS that failed genotyping in the present study. Additionally we report moderate associations at the 3’ end of PLD5 in meta-analysis (3.2 x 10−4 ≤ p ≤ 5.8 x 10−4). Conclusion: We report replication data suggesting that RGS7, a gene abundantly expressed in the brain, might be a putative body fat QTL on human chromosome 1q43. Future genetic and functional studies are required to substantiate our observations and to potentially link them to the neurobehavioral phenotypes associated with the RGS7 region.

Suggested Citation

  • Brahim Aissani & Howard W Wiener & Kui Zhang, 2016. "Fine Mapping of the Body Fat QTL on Human Chromosome 1q43," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-13, April.
  • Handle: RePEc:plo:pone00:0153794
    DOI: 10.1371/journal.pone.0153794
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    1. Gareth E. Lim & Tobias Albrecht & Micah Piske & Karnjit Sarai & Jason T. C Lee & Hayley S. Ramshaw & Sunita Sinha & Mark A. Guthridge & Amparo Acker-Palmer & Angel F. Lopez & Susanne M. Clee & Corey N, 2015. "14-3-3ζ coordinates adipogenesis of visceral fat," Nature Communications, Nature, vol. 6(1), pages 1-17, November.
    2. Lavinia Paternoster & Mattias Lorentzon & Terho Lehtimäki & Joel Eriksson & Mika Kähönen & Olli Raitakari & Marika Laaksonen & Harri Sievänen & Jorma Viikari & Leo-Pekka Lyytikäinen & Dan Mellström & , 2013. "Genetic Determinants of Trabecular and Cortical Volumetric Bone Mineral Densities and Bone Microstructure," PLOS Genetics, Public Library of Science, vol. 9(2), pages 1-15, February.
    3. Masahisa Yamada & Tsuyoshi Miyakawa & Alokesh Duttaroy & Akihiro Yamanaka & Toru Moriguchi & Ryosuke Makita & Masaharu Ogawa & Chieh J. Chou & Bing Xia & Jacqueline N. Crawley & Christian C. Felder & , 2001. "Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean," Nature, Nature, vol. 410(6825), pages 207-212, March.
    4. André Scherag & Christian Dina & Anke Hinney & Vincent Vatin & Susann Scherag & Carla I G Vogel & Timo D Müller & Harald Grallert & H-Erich Wichmann & Beverley Balkau & Barbara Heude & Marjo-Riitta Ja, 2010. "Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups," PLOS Genetics, Public Library of Science, vol. 6(4), pages 1-10, April.
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