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Prediction of the Chemoreflex Gain by Common Clinical Variables in Heart Failure

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  • Gianluca Mirizzi
  • Alberto Giannoni
  • Andrea Ripoli
  • Giovanni Iudice
  • Francesca Bramanti
  • Michele Emdin
  • Claudio Passino

Abstract

Background: Peripheral and central chemoreflex sensitivity, assessed by the hypoxic or hypercapnic ventilatory response (HVR and HCVR, respectively), is enhanced in heart failure (HF) patients, is involved in the pathophysiology of the disease, and is under investigation as a potential therapeutic target. Chemoreflex sensitivity assessment is however demanding and, therefore, not easily applicable in the clinical setting. We aimed at evaluating whether common clinical variables, broadly obtained by routine clinical and instrumental evaluation, could predict increased HVR and HCVR. Methods and results: 191 patients with systolic HF (left ventricular ejection fraction—LVEF—

Suggested Citation

  • Gianluca Mirizzi & Alberto Giannoni & Andrea Ripoli & Giovanni Iudice & Francesca Bramanti & Michele Emdin & Claudio Passino, 2016. "Prediction of the Chemoreflex Gain by Common Clinical Variables in Heart Failure," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0153510
    DOI: 10.1371/journal.pone.0153510
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