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The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch–Schönlein Purpura

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  • Chan Hyuk Park
  • Dong Soo Han
  • Jae Yoon Jeong
  • Chang Soo Eun
  • Kyo-Sang Yoo
  • Yong Cheol Jeon
  • Joo Hyun Sohn

Abstract

Background: The development of gastrointestinal (GI) bleeding and end-stage renal disease (ESRD) can be a concern in the management of Henoch–Schönlein purpura (HSP). We aimed to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is associated with the prognosis of adult patients with HSP. Methods: Clinical data including the NLR of adult patients with HSP were retrospectively analyzed. Patients were classified into three groups as follows: (a) simple recovery, (b) wax & wane without GI bleeding, and (c) development of GI bleeding. The optimal cut-off value was determined using a receiver operating characteristics curve and the Youden index. Results: A total of 66 adult patients were enrolled. The NLR was higher in the GI bleeding group than in the simple recovery or wax & wane group (simple recovery vs. wax & wane vs. GI bleeding; median [IQR], 2.32 [1.61–3.11] vs. 3.18 [2.16–3.71] vs. 7.52 [4.91–10.23], P

Suggested Citation

  • Chan Hyuk Park & Dong Soo Han & Jae Yoon Jeong & Chang Soo Eun & Kyo-Sang Yoo & Yong Cheol Jeon & Joo Hyun Sohn, 2016. "The Optimal Cut-Off Value of Neutrophil-to-Lymphocyte Ratio for Predicting Prognosis in Adult Patients with Henoch–Schönlein Purpura," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0153238
    DOI: 10.1371/journal.pone.0153238
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