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Beneficial Effect of Moderate Exercise in Kidney of Rat after Chronic Consumption of Cola Drinks

Author

Listed:
  • Gabriel Cao
  • Julián González
  • Angélica Müller
  • Graciela Ottaviano
  • Giuseppe Ambrosio
  • Jorge E Toblli
  • José Milei

Abstract

Aim: The purpose of this study was to investigate the effect of moderate intensity exercise on kidney in an animal model of high consumption of cola soft drinks. Methods: Forty-eight Wistar Kyoto rats (age: 16 weeks; weight: 350–400 g) were assigned to the following groups: WR (water runners) drank water and submitted to aerobic exercise; CR (cola runners) drank cola and submitted to aerobic exercise; WS (water sedentary) and CS (cola sedentary), not exercised groups. The aerobic exercise was performed for 5 days per week throughout the study (24 weeks) and the exercise intensity was gradually increased during the first 8 weeks until it reached 20 meters / minute for 30 minutes. Body weight, lipid profile, glycemia, plasma creatinine levels, atherogenic index of plasma (AIP) and systolic blood pressure (SBP) were determined. After 6 months all rats were sacrificed. A kidney histopathological score was obtained using a semiquantitative scale. Glomerular size and glomerulosclerosis were estimated by point-counting. The oxidative stress and pro-inflammatory status were explored by immunohistochemistry. A one way analysis of variance (ANOVA) with Tukey-Kramer post-hoc test or the Kruskal-Wallis test with Dunn’s post-hoc test was used for statistics. A value of p

Suggested Citation

  • Gabriel Cao & Julián González & Angélica Müller & Graciela Ottaviano & Giuseppe Ambrosio & Jorge E Toblli & José Milei, 2016. "Beneficial Effect of Moderate Exercise in Kidney of Rat after Chronic Consumption of Cola Drinks," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0152461
    DOI: 10.1371/journal.pone.0152461
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