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Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2

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  • Takanobu Nagata
  • Hiroshi Sobajima
  • Norimi Ohashi
  • Akihiro Hirakawa
  • Takayuki Katsuno
  • Yoshinari Yasuda
  • Seiichi Matsuo
  • Naotake Tsuboi
  • Shoichi Maruyama

Abstract

Background: Data regarding the association between 24h urinary sodium and potassium excretion with kidney outcomes in patients with diabetes mellitus is currently scarce. Methods: We conducted a single-center, retrospective cohort study in which 1230 patients with diabetes who had undergone a 24h urinary sodium and potassium excretion test were analyzed. Patients with incomplete urine collection were excluded based on 24h urinary creatinine excretion. Outcomes were the composite of a 30% decline in eGFR or death. Multivariate cox regression analysis was used to investigate the association between urinary sodium and potassium excretion and outcomes. Results: With a mean follow up period of 5.47 years, 130 patients reached the outcomes (30% decline in eGFR: 124, death: 6). Mean (SD) eGFR and 24h urinary sodium and potassium excretion at baseline were 78.6 (19.5) ml/min/1.73m2, 4.50 (1.64) g/day, and 2.14 (0.77) g/day. Compared with sodium excretion

Suggested Citation

  • Takanobu Nagata & Hiroshi Sobajima & Norimi Ohashi & Akihiro Hirakawa & Takayuki Katsuno & Yoshinari Yasuda & Seiichi Matsuo & Naotake Tsuboi & Shoichi Maruyama, 2016. "Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0152306
    DOI: 10.1371/journal.pone.0152306
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