IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0152152.html
   My bibliography  Save this article

Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue

Author

Listed:
  • Araminta E W Ledger
  • Erica D Scurr
  • Julie Hughes
  • Alison Macdonald
  • Toni Wallace
  • Karen Thomas
  • Robin Wilson
  • Martin O Leach
  • Maria A Schmidt

Abstract

Objectives: To evaluate sources of error in the Magnetic Resonance Imaging (MRI) measurement of percent fibroglandular tissue (%FGT) using two-point Dixon sequences for fat-water separation. Methods: Ten female volunteers (median age: 31 yrs, range: 23–50 yrs) gave informed consent following Research Ethics Committee approval. Each volunteer was scanned twice following repositioning to enable an estimation of measurement repeatability from high-resolution gradient-echo (GRE) proton-density (PD)-weighted Dixon sequences. Differences in measures of %FGT attributable to resolution, T1 weighting and sequence type were assessed by comparison of this Dixon sequence with low-resolution GRE PD-weighted Dixon data, and against gradient-echo (GRE) or spin-echo (SE) based T1-weighted Dixon datasets, respectively. Results: %FGT measurement from high-resolution PD-weighted Dixon sequences had a coefficient of repeatability of ±4.3%. There was no significant difference in %FGT between high-resolution and low-resolution PD-weighted data. Values of %FGT from GRE and SE T1-weighted data were strongly correlated with that derived from PD-weighted data (r = 0.995 and 0.96, respectively). However, both sequences exhibited higher mean %FGT by 2.9% (p

Suggested Citation

  • Araminta E W Ledger & Erica D Scurr & Julie Hughes & Alison Macdonald & Toni Wallace & Karen Thomas & Robin Wilson & Martin O Leach & Maria A Schmidt, 2016. "Comparison of Dixon Sequences for Estimation of Percent Breast Fibroglandular Tissue," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0152152
    DOI: 10.1371/journal.pone.0152152
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152152
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152152&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0152152?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0152152. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.