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Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration

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  • Erna Morden
  • Karl-Günter Technau
  • Janet Giddy
  • Nicola Maxwell
  • Olivia Keiser
  • Mary-Ann Davies

Abstract

Background: HIV-exposed uninfected (HEU) infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT) antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth within the first 28 weeks of life. Methods: This is a retrospective cohort based on routine clinical data from two South African PMTCT programmes. Data were collected between 2007 and 2013. Linear regression assessed factors affecting birth weight-for-age z-scores (WAZ) while growth (longitudinal WAZ) was assessed using mixed effects models. Results: We assessed the growth of 2621 HEU infants (median birth WAZ was -0.65 (IQR -1.46; 0.0) and 51% were male). The feeding modalities practised were as follows: 0.5% exclusive breastfeeding, 7.9% breastfeeding with unknown exclusivity, 0.08% mixed breastfeeding and 89.2% formula feeding. Mothers with CD4

Suggested Citation

  • Erna Morden & Karl-Günter Technau & Janet Giddy & Nicola Maxwell & Olivia Keiser & Mary-Ann Davies, 2016. "Growth of HIV-Exposed Uninfected Infants in the First 6 Months of Life in South Africa: The IeDEA-SA Collaboration," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0151762
    DOI: 10.1371/journal.pone.0151762
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