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Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort

Author

Listed:
  • Graham R Foster
  • Carmine Coppola
  • Moutaz Derbala
  • Peter Ferenci
  • Alessandra Orlandini
  • K Rajender Reddy
  • Ludovico Tallarico
  • Mitchell L Shiffman
  • Silke Ahlers
  • Georgios Bakalos
  • Tarek Hassanein
  • GUARD-C Study Group

Abstract

Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA

Suggested Citation

  • Graham R Foster & Carmine Coppola & Moutaz Derbala & Peter Ferenci & Alessandra Orlandini & K Rajender Reddy & Ludovico Tallarico & Mitchell L Shiffman & Silke Ahlers & Georgios Bakalos & Tarek Hassan, 2016. "Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-20, March.
    • Handle: RePEc:plo:pone00:0151703
    DOI: 10.1371/journal.pone.0151703
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