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Altered Cerebellar White Matter Integrity in Patients with Mild Traumatic Brain Injury in the Acute Stage

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  • Zhongqiu Wang
  • Wenzhong Wu
  • Yongkang Liu
  • Tianyao Wang
  • Xiao Chen
  • Jianhua Zhang
  • Guoxing Zhou
  • Rong Chen

Abstract

Background and Purpose: Imaging studies of traumatic brain injury demonstrate that the cerebellum is often affected. We aim to examine fractional anisotropy alteration in acute-phase mild traumatic brain injury patients in cerebellum-related white matter tracts. Materials and Methods: This prospective study included 47 mild traumatic brain injury patients in the acute stage and 37 controls. MR imaging and neurocognitive tests were performed in patients within 7 days of injury. White matter integrity was examined by using diffusion tensor imaging. We used three approaches, tract-based spatial statistics, graphical-model-based multivariate analysis, and region-of-interest analysis, to detect altered cerebellar white matter integrity in mild traumatic brain injury patients. Results: Results from three analysis methods were in accordance with each other, and suggested fractional anisotropy in the middle cerebellar peduncle and the pontine crossing tract was changed in the acute-phase mild traumatic brain injury patients, relative to controls (adjusted p-value

Suggested Citation

  • Zhongqiu Wang & Wenzhong Wu & Yongkang Liu & Tianyao Wang & Xiao Chen & Jianhua Zhang & Guoxing Zhou & Rong Chen, 2016. "Altered Cerebellar White Matter Integrity in Patients with Mild Traumatic Brain Injury in the Acute Stage," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0151489
    DOI: 10.1371/journal.pone.0151489
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