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Prenatal Diagnosis and Evaluation of Sonographic Predictors for Intervention and Adverse Outcome in Congenital Pulmonary Airway Malformation

Author

Listed:
  • Astrid Hellmund
  • Christoph Berg
  • Annegret Geipel
  • Meike Bludau
  • Andreas Heydweiller
  • Haitham Bachour
  • Andreas Müller
  • Annette Müller
  • Ulrich Gembruch

Abstract

Objective: To describe antenatal findings and evaluate prenatal risk parameters for adverse outcome or need for intervention in fetuses with congenital pulmonary airway malformation (CPAM). Methods: In our retrospective study all fetuses with a prenatal diagnosis of CPAM detected in our tertiary referral center between 2002 and 2013 were analyzed. Sonographic findings were noted and measurements of mass-to-thorax-ratio (MTR), congenital pulmonary airway malformation volume-ratio (CVR) and observed to expected lung-to head-ratio (o/e LHR) were conducted and correlated to fetal or neonatal morbidity and mortality and/or need for prenatal intervention. Results: 67 fetuses with CPAM were included in the study. Hydropic fetuses were observed in 16.4% (11/67) of cases, prenatal intervention was undertaken in 9 cases; 7 pregnancies were terminated. The survival rate of non-hydropic fetuses with conservatively managed CPAM was 98.0% (50/51), the survival rate for hydropic fetuses with intention to treat was 42.9% (3/7). 10 (18.2%) children needed respiratory assistance. Fetuses with a CVR of

Suggested Citation

  • Astrid Hellmund & Christoph Berg & Annegret Geipel & Meike Bludau & Andreas Heydweiller & Haitham Bachour & Andreas Müller & Annette Müller & Ulrich Gembruch, 2016. "Prenatal Diagnosis and Evaluation of Sonographic Predictors for Intervention and Adverse Outcome in Congenital Pulmonary Airway Malformation," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0150474
    DOI: 10.1371/journal.pone.0150474
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