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Clinical Assessment of Lamina Cribrosa Curvature in Eyes with Primary Open-Angle Glaucoma

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Listed:
  • Yong Woo Kim
  • Jin Wook Jeoung
  • Dai Woo Kim
  • Michael J A Girard
  • Jean Martial Mari
  • Ki Ho Park
  • Dong Myung Kim

Abstract

Purpose: Quantitative evaluation of lamina cribrosa (LC) posterior bowing in primary open-angle glaucoma (POAG) eyes using swept-source optical coherence tomography. Methods: Patients with POAG (n = 123 eyes) and healthy individuals of a similar age (n = 92 eyes) were prospectively recruited. Anterior laminar insertion depth (ALID) was defined as the vertical distance between the anterior laminar insertion and a reference plane connecting the Bruch’s membrane openings (BMO). The mean LC depth (mLCD) was approximated by dividing the area enclosed by the anterior LC, the BMO reference plane, and the two vertical lines for ALID measurement by the length between those two vertical lines. The LC curvature index was defined as the difference between the mLCD and the ALID. The factors influencing the LC curvature index were evaluated. Results: The ALID and mLCD were significantly larger in POAG eyes than in healthy controls (P –6 dB) and moderate-to-advanced glaucoma (MD

Suggested Citation

  • Yong Woo Kim & Jin Wook Jeoung & Dai Woo Kim & Michael J A Girard & Jean Martial Mari & Ki Ho Park & Dong Myung Kim, 2016. "Clinical Assessment of Lamina Cribrosa Curvature in Eyes with Primary Open-Angle Glaucoma," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0150260
    DOI: 10.1371/journal.pone.0150260
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