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Quantification of 18FDG in the Normal Colon—A First Step in Investigating Whether Its Presence Is a Marker of a Physiological Process

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  • Karna D Bardhan
  • James Cullis
  • Nigel R Williams
  • Ramesh P Arasaradnam
  • Adrian J Wilson

Abstract

The visibility of the colon in positron emission tomography (PET) scans of patients without gastrointestinal disease indicating the presence of 18F Fluorodeoxyglucose (18FDG) is well recognised, but unquantified and unexplained. In this paper a qualitative scoring system was applied to PET scans from 30 randomly selected patients without gastrointestinal disease to detect the presence of 18FDG in 4 different sections of the colon and then both the total pixel value and the pixel value per unit length of each section of the colon were determined to quantify the amount of 18FDG from a randomly selected subset of 10 of these patients. Analysis of the qualitative scores using a non-parametric ANOVA showed that all sections of the colon contained 18FDG but there were differences in the amount of 18FDG present between sections (p 0.05), but a difference in the amount/unit length between sections (p

Suggested Citation

  • Karna D Bardhan & James Cullis & Nigel R Williams & Ramesh P Arasaradnam & Adrian J Wilson, 2016. "Quantification of 18FDG in the Normal Colon—A First Step in Investigating Whether Its Presence Is a Marker of a Physiological Process," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0147838
    DOI: 10.1371/journal.pone.0147838
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