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The Defect in Autophagy Induction by Clinical Isolates of Mycobacterium Tuberculosis Is Correlated with Poor Tuberculosis Outcomes

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  • Furong Li
  • Bo Gao
  • Wei Xu
  • Ling Chen
  • Sidong Xiong

Abstract

Background: Tuberculosis (TB) represents a major global health problem. The prognosis of clinically active tuberculosis depends on the complex interactions between Mycobacterium tuberculosis (Mtb) and its host. In recent years, autophagy receives particular attention for its role in host defense against intracellular pathogens, including Mtb. In present study, we aim to investigate the relationship of autophagy induction by clinical isolates of Mtb with the clinical outcomes in patients with TB. Methodology/Principal Findings: We collected 185 clinical isolates of Mtb, and determined the effect of these Mtb isolates on autophagy induction in macrophages. It was found that most of clinical isolates of Mtb were able to induce autophagosome formation in macrophages, however, the autophagy-inducing ability varied significantly among different isolates. Of importance, our results revealed that patients infected by Mtb with poor autophagy-inducing ability displayed more severe radiographic extent of disease (p

Suggested Citation

  • Furong Li & Bo Gao & Wei Xu & Ling Chen & Sidong Xiong, 2016. "The Defect in Autophagy Induction by Clinical Isolates of Mycobacterium Tuberculosis Is Correlated with Poor Tuberculosis Outcomes," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0147810
    DOI: 10.1371/journal.pone.0147810
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