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Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies

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  • Yanguo Feng
  • Dejun Cheng
  • Chaofeng Zhang
  • Yuchun Li
  • Zhiying Zhang
  • Juan Wang
  • Yuzhong Shi

Abstract

Background: The PDE4B single nucleotide polymorphisms (SNPs) have been reported to be associated with schizophrenia risk. However, current findings are ambiguous or even conflicting. To better facilitate the understanding the genetic role played by PDE4B in susceptibility to schizophrenia, we collected currently available data and conducted this meta-analysis. Methods: A comprehensive electronic literature searching of PubMed, Embase, Web of Science and Cochrane Library was performed. The association between PDE4B SNPs and schizophrenia was evaluated by odds ratios (ORs) and 95% confidence intervals (CIs) under allelic, dominant and recessive genetic models. The random effects model was utilized when high between-study heterogeneity (I2 > 50%) existed, otherwise the fixed effects model was used. Results: Five studies comprising 2376 schizophrenia patients and 3093 controls were finally included for meta-analysis. The rs1040716 was statistically significantly associated with schizophrenia risk in Asian and Caucasian populations under dominant model (OR = 0.87, 95% CI: 0.76–0.99, P = 0.04). The rs2180335 was significantly related with schizophrenia risk in Asian populations under allelic (OR = 0.82, 95% CI: 0.72–0.93, P = 0.003) and dominant (OR = 0.75, 95% CI: 0.64–0.88, P

Suggested Citation

  • Yanguo Feng & Dejun Cheng & Chaofeng Zhang & Yuchun Li & Zhiying Zhang & Juan Wang & Yuzhong Shi, 2016. "Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0147092
    DOI: 10.1371/journal.pone.0147092
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