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Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans

Author

Listed:
  • Yolanda Saldaña-Alvarez
  • María Guadalupe Salas-Martínez
  • Humberto García-Ortiz
  • Angélica Luckie-Duque
  • Gustavo García-Cárdenas
  • Hermenegildo Vicenteño-Ayala
  • Emilio J Cordova
  • Marcelino Esparza-Aguilar
  • Cecilia Contreras-Cubas
  • Alessandra Carnevale
  • Margarita Chávez-Saldaña
  • Lorena Orozco

Abstract

To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study of 2314 unrelated Mexican-Mestizo adult subjects was performed. The association between each SNP and BMI was tested using logistic and linear regression adjusted for age, gender, and ancestry and assuming additive, recessive, and dominant effects of the minor allele. Association analysis after BMI stratification showed that all five FTO SNPs (rs1121980, rs17817449, rs3751812, rs9930506, and rs17817449), were significantly associated with obesity class II/III under an additive model (P

Suggested Citation

  • Yolanda Saldaña-Alvarez & María Guadalupe Salas-Martínez & Humberto García-Ortiz & Angélica Luckie-Duque & Gustavo García-Cárdenas & Hermenegildo Vicenteño-Ayala & Emilio J Cordova & Marcelino Esparza, 2016. "Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0145984
    DOI: 10.1371/journal.pone.0145984
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    1. Zhifu Han & Tianhui Niu & Junbiao Chang & Xiaoguang Lei & Mingyan Zhao & Qiang Wang & Wei Cheng & Jinjing Wang & Yi Feng & Jijie Chai, 2010. "Crystal structure of the FTO protein reveals basis for its substrate specificity," Nature, Nature, vol. 464(7292), pages 1205-1209, April.
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