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HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011–2013)

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  • Seok Hui Kang
  • Da Jung Jung
  • Eun Woo Choi
  • Kyu Hyang Cho
  • Jong Won Park
  • Jun Young Do

Abstract

Background: Many studies have reported an association between glycated hemoglobin A1c (HbA1c) and metabolic syndrome (MetS) in non-diabetes patients. Each component of MetS is in fact related to chronic kidney disease (CKD) incidence and progression. Therefore, HbA1c in non-diabetic mellitus (DM) may be intrinsically associated with the prevalence of CKD. The hypothesis of the present study was that high HbA1c in non-DM patients is associated with CKD. Patients and Methods: The total number of participants in this study was 24,594. The participants were divided into three groups according to their HbA1c levels: a Low group ( 6.0% or >42 mmol/mol). The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Results: The number of participants allocated to the Low, Middle, and High groups was 8,651, 4,634, and 1,387, respectively. Linear regression analyses were performed to evaluate the association between variables. Standardized β ± standard error was 0.25 ± 0.22 for waist circumference, 0.44 ± 0.20 for fasting glucose, –0.14 ± 0.30 for high-density lipoprotein cholesterol levels, 0.15 ± 2.31 for triglyceride levels, 0.21 ± 0.00 for systolic blood pressure, 0.10 ± 0.00 for diastolic blood pressure, and –0.22 ± 0.42 for eGFR (P

Suggested Citation

  • Seok Hui Kang & Da Jung Jung & Eun Woo Choi & Kyu Hyang Cho & Jong Won Park & Jun Young Do, 2015. "HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011–2013)," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0145827
    DOI: 10.1371/journal.pone.0145827
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