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Identification of Risk Factors for Locoregional Recurrence in Breast Cancer Patients with Nodal Stage N0 and N1: Who Could Benefit from Post-Mastectomy Radiotherapy?

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  • Eunjin Jwa
  • Kyung Hwan Shin
  • Hyeon Woo Lim
  • So-Youn Jung
  • Seeyoun Lee
  • Han-Sung Kang
  • EunSook Lee
  • Young Hee Park

Abstract

Introduction: The locoregional recurrence (LRR) rate was reported as high as approximately 20% in stage I-II breast cancer following mastectomy. To investigate the risk factors for LRR in pT1–2N0-1 breast cancer patients treated with mastectomy but not radiation, and to define a subgroup of patients at high risk of LRR who may benefit from postmastectomy radiotherapy (PMRT). Methods and Materials: In total, 390 patients with pT1-2N0M0 (n = 307) and pT1-2N1M0 (n = 83) breast cancer who underwent total mastectomy without adjuvant radiotherapy from 2002 to 2011 were enrolled in the study. Results: After a median follow-up period of 5.6 years (range, 0.6–11.3 years), 21 patients had 18 systemic relapses and 12 LRRs including six in the chest wall and eight in the regional nodal area. The 5-year LRR-free survival (LRRFS) rates were 97.0% in pN0, 98.8% in pN1, and 97.4% in all patients. Multivariate analysis revealed that age

Suggested Citation

  • Eunjin Jwa & Kyung Hwan Shin & Hyeon Woo Lim & So-Youn Jung & Seeyoun Lee & Han-Sung Kang & EunSook Lee & Young Hee Park, 2015. "Identification of Risk Factors for Locoregional Recurrence in Breast Cancer Patients with Nodal Stage N0 and N1: Who Could Benefit from Post-Mastectomy Radiotherapy?," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0145463
    DOI: 10.1371/journal.pone.0145463
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