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Clinical Characteristics of 582 Patients with Uveal Melanoma in China

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  • Yue Ming Liu
  • Yang Li
  • Wen Bin Wei
  • Xiaolin Xu
  • Jost B Jonas

Abstract

Objective: To assess clinical characteristics, treatment and survival of patients with uveal melanoma in China. Methods: The retrospective study included all patients with malignant uveal melanoma who were consecutively examined in the study period from January 2005 and June 2015 in the Beijing Tongren hospital. Results: The mean age of the 582 patients (295(50.7%) women) was 44.6±12.6 years (range:5–77 years). The tumors were located most often in the superior temporal region (in 117(21.5%) patients) and least common in the inferior region (in 31(5.7%) patients). In 548(94.2%) patients, the tumors were located in the choroid, in 33(5.7%) patients in the ciliary body, and in one (0.2%) patient in the iris. Treatment included episcleral brachytherapy (415(71.3%) patients), local tumor resection (48(8.2%) patients) and primary enucleation (119(20.4%) patients). In 53 individuals out of the 415 patients with primary brachytherapy, episcleral brachytherapy was followed by enucleation, due to an increasing tumor size or due to uncontrolled neovascular glaucoma. Median follow-up time was of 30 months (range: 1–124 months; mean: 34.8 ± 24.4 months). Overall survival rate at 5 and 10 years was of 92.7% and 85.1%. Younger age (P = 0.017), tumor location in the nasal meridian(P = 0.004), smaller tumor size (P

Suggested Citation

  • Yue Ming Liu & Yang Li & Wen Bin Wei & Xiaolin Xu & Jost B Jonas, 2015. "Clinical Characteristics of 582 Patients with Uveal Melanoma in China," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0144562
    DOI: 10.1371/journal.pone.0144562
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