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Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians

Author

Listed:
  • Yuri Miura
  • Noritaka Hashii
  • Hiroki Tsumoto
  • Daisuke Takakura
  • Yuki Ohta
  • Yukiko Abe
  • Yasumichi Arai
  • Nana Kawasaki
  • Nobuyoshi Hirose
  • Tamao Endo
  • SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians)

Abstract

An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a graphitized carbon column. Characteristic N-glycans in SSCs were discriminated using a multivariate analysis; orthogonal projections to latent structures (O-PLS). The results obtained showed that multi-branched and highly sialylated N-glycans as well as agalacto- and/or bisecting N-glycans were increased in SSCs, while biantennary N-glycans were decreased. Since multi-branched and highly sialylated N-glycans have been implicated in anti-inflammatory activities, these changes may play a role in the enhanced chronic inflammation observed in SSCs. The levels of inflammatory proteins, such as CRP, adiponectin, IL-6, and TNF-α, were elevated in SSCs. These results suggested that responses to inflammation may play an important role in extreme longevity and healthy aging in humans. This is the first study to show that the N-glycans of plasma proteins were associated with extreme longevity and healthy aging in humans.

Suggested Citation

  • Yuri Miura & Noritaka Hashii & Hiroki Tsumoto & Daisuke Takakura & Yuki Ohta & Yukiko Abe & Yasumichi Arai & Nana Kawasaki & Nobuyoshi Hirose & Tamao Endo & SONIC (Septuagenarians, Octogenarians, Nona, 2015. "Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-14, November.
    • Handle: RePEc:plo:pone00:0142645
    DOI: 10.1371/journal.pone.0142645
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