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Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up

Author

Listed:
  • Mirthe E van der Valk
  • Marie-Josée J Mangen
  • Mirjam Severs
  • Mike van der Have
  • Gerard Dijkstra
  • Ad A van Bodegraven
  • Herma H Fidder
  • Dirk J de Jong
  • C Janneke van der Woude
  • Mariëlle J L Romberg-Camps
  • Cees H M Clemens
  • Jeroen M Jansen
  • Paul C van de Meeberg
  • Nofel Mahmmod
  • Andrea E van der Meulen-de Jong
  • Cyriel Y Ponsioen
  • Clemens Bolwerk
  • J Reinoud Vermeijden
  • Peter D Siersema
  • Max Leenders
  • Bas Oldenburg
  • COIN study group and the Dutch Initiative on Crohn and Colitis

Abstract

Background: With the increasing use of anti-TNF therapy in inflammatory bowel disease (IBD), a shift of costs has been observed with medication costs replacing hospitalization and surgery as major cost driver. We aimed to explore the evolution of IBD-related costs over two years of follow-up. Methods and Findings: In total 1,307 Crohn's disease (CD) patients and 915 ulcerative colitis (UC) patients were prospectively followed for two years by three-monthly web-based questionnaires. Changes of healthcare costs, productivity costs and out-of-pocket costs over time were assessed using mixed model analysis. Multivariable logistic regression analysis was used to identify costs drivers. In total 737 CD patients and 566 UC were included. Total costs were stable over two years of follow-up, with annual total costs of €7,835 in CD and €3,600 in UC. However, within healthcare costs, the proportion of anti-TNF therapy-related costs increased from 64% to 72% in CD (p

Suggested Citation

  • Mirthe E van der Valk & Marie-Josée J Mangen & Mirjam Severs & Mike van der Have & Gerard Dijkstra & Ad A van Bodegraven & Herma H Fidder & Dirk J de Jong & C Janneke van der Woude & Mariëlle J L Romb, 2016. "Evolution of Costs of Inflammatory Bowel Disease over Two Years of Follow-Up," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0142481
    DOI: 10.1371/journal.pone.0142481
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    References listed on IDEAS

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    1. Anne Prenzler & Bernd Bokemeyer & J.-Matthias Schulenburg & Thomas Mittendorf, 2011. "Health care costs and their predictors of inflammatory bowel diseases in Germany," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 12(3), pages 273-283, June.
    2. Renee Stark & Hans-Helmut König & Reiner Leidl, 2006. "Costs of Inflammatory Bowel Disease in Germany," PharmacoEconomics, Springer, vol. 24(8), pages 797-814, August.
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    1. Przemysław Holko & Paweł Kawalec & Magdalena Sajak-Szczerba & Luisa Avedano & Małgorzata Mossakowska, 2023. "Out-of-pocket expenses of patients with inflammatory bowel disease: a comparison of patient-reported outcomes across 12 European countries," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(7), pages 1073-1083, September.

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