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Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants

Author

Listed:
  • Eugenie Poirot
  • Eric Vittinghoff
  • Deus Ishengoma
  • Michael Alifrangis
  • Ilona Carneiro
  • Ramadhan Hashim
  • Vito Baraka
  • Jacklin Mosha
  • Samwel Gesase
  • Daniel Chandramohan
  • Roland Gosling

Abstract

Background: Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children. Few studies have explored the effects of G6PD status on hemolysis in children treated with Intermittent Preventive Treatment in infants (IPTi) antimalarial regimens. We sought to examine the joint effects of G6PD status and IPTi antimalarial treatment on incidence of hemolysis in asymptomatic children treated with CD, sulfadoxine-pyrimethamine (SP), and mefloquine (MQ). Methods: A secondary analysis of data from a double-blind, placebo-controlled trial of IPTi was conducted. Hemoglobin (Hb) measurements were made at IPTi doses, regular follow-up and emergency visits. G6PD genotype was determined at 9 months looking for SNPs for the A- genotype at coding position 202. Multivariable linear and logistic regression models were used to examine hemolysis among children with valid G6PD genotyping results. Hemolysis was defined as the absolute change in Hb or as any post-dose Hb

Suggested Citation

  • Eugenie Poirot & Eric Vittinghoff & Deus Ishengoma & Michael Alifrangis & Ilona Carneiro & Ramadhan Hashim & Vito Baraka & Jacklin Mosha & Samwel Gesase & Daniel Chandramohan & Roland Gosling, 2015. "Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of M," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0142414
    DOI: 10.1371/journal.pone.0142414
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