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Impact of Statins on Gene Expression in Human Lung Tissues

Author

Listed:
  • Jérôme Lane
  • Stephan F van Eeden
  • Ma’en Obeidat
  • Don D Sin
  • Scott J Tebbutt
  • Wim Timens
  • Dirkje S Postma
  • Michel Laviolette
  • Peter D Paré
  • Yohan Bossé

Abstract

Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that alter the synthesis of cholesterol. Some studies have shown a significant association of statins with improved respiratory health outcomes of patients with asthma, chronic obstructive pulmonary disease and lung cancer. Here we hypothesize that statins impact gene expression in human lungs and may reveal the pleiotropic effects of statins that are taking place directly in lung tissues. Human lung tissues were obtained from patients who underwent lung resection or transplantation. Gene expression was measured on a custom Affymetrix array in a discovery cohort (n = 408) and two replication sets (n = 341 and 282). Gene expression was evaluated by linear regression between statin users and non-users, adjusting for age, gender, smoking status, and other covariables. The results of each cohort were combined in a meta-analysis and biological pathways were studied using Gene Set Enrichment Analysis. The discovery set included 141 statin users. The lung mRNA expression levels of eighteen and three genes were up-regulated and down-regulated in statin users (FDR

Suggested Citation

  • Jérôme Lane & Stephan F van Eeden & Ma’en Obeidat & Don D Sin & Scott J Tebbutt & Wim Timens & Dirkje S Postma & Michel Laviolette & Peter D Paré & Yohan Bossé, 2015. "Impact of Statins on Gene Expression in Human Lung Tissues," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-19, November.
    • Handle: RePEc:plo:pone00:0142037
    DOI: 10.1371/journal.pone.0142037
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