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Effect of Prolonged Radiotherapy Treatment Time on Survival Outcomes after Intensity-Modulated Radiation Therapy in Nasopharyngeal Carcinoma

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Listed:
  • Pei-Jing Li
  • Ting Jin
  • Dong-Hua Luo
  • Ting Shen
  • Dong-Mei Mai
  • Wei-Han Hu
  • Hao-Yuan Mo

Abstract

Purpose: To estimate the influence of prolonged radiation treatment time (RTT) on survival outcomes in nasopharyngeal carcinoma after continuous intensity-modulated radiation therapy. Methods and Materials: Retrospectively review 321 patients with NPC treated between October 2009 and December 2010 and all of them underwent simultaneous accelerated intensity-modulated radiation therapy. The fractionated dose was 2–2.47 Gy/F (median 2.27 Gy), and the total dose for nasopharyngeal region was 64–74 Gy/ 28–33 fractions. The association of prolonged RTT and treatment interruption with PFS, LRFS and DFFS were assessed by univariate analysis and multivariate analysis. Survival analyses were carried out using Kaplan–Meier methodology and the log-rank test was used to assess the difference. The Cox regression proportional hazard model was used for multivariate analyses and evaluating the prognostic parameters for PFS, LRFS and DFFS. Results: Univariate analysis revealed no significant associations between prolonged RTT and PFS, LRFS, DFFS when dichotomized using various cut-off values (all P>0.05). In multivariate analysis, RTT (range, 36–63 days) as a continuous variable, had no influence on any survival outcome as well (P>0.05). T and N classification were independent prognostic factors for PFS, LRFS and DFFS (all P

Suggested Citation

  • Pei-Jing Li & Ting Jin & Dong-Hua Luo & Ting Shen & Dong-Mei Mai & Wei-Han Hu & Hao-Yuan Mo, 2015. "Effect of Prolonged Radiotherapy Treatment Time on Survival Outcomes after Intensity-Modulated Radiation Therapy in Nasopharyngeal Carcinoma," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.
    • Handle: RePEc:plo:pone00:0141332
    DOI: 10.1371/journal.pone.0141332
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    1. Dyna Doum & Hans J. Overgaard & Mayfong Mayxay & Sutas Suttiprapa & Prasert Saichua & Tipaya Ekalaksananan & Panwad Tongchai & Md. Siddikur Rahman & Ubydul Haque & Sysavanh Phommachanh & Tiengkham Pon, 2020. "Dengue Seroprevalence and Seroconversion in Urban and Rural Populations in Northeastern Thailand and Southern Laos," IJERPH, MDPI, vol. 17(23), pages 1-19, December.

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